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DS is a 27 year old male who comes to the pharmacy seeking advice because, for the past 24 hours, he has experienced abdominal cramping, mild fever and frequent, loose stools with some blood loss. DS thinks it may be related to the antibiotic he has been taking for a dental abscess. Current medications include: clindamycin 150 mg po qid x10 days, started 8 days ago, and losartan 25 mg po daily for hypertension, started 3 months ago. The most appropriate pharmacist response is that these symptoms:

  1. Are expected, transient side-effects of clindamycin; treat symptoms and continue medications.

  2. May indicate an interaction between clindamycin and losartan; pharmacist call to dentist is warranted.

  3. May indicate clindamycin-related pseudomembranous colitis; seek immediate medical attention.

  4. Are probably unrelated to DS’s medications; treat for flu symptoms and follow-up if no improvement.

The correct answer is: May indicate clindamycin-related pseudomembranous colitis; seek immediate medical attention.

These symptoms may indicate a serious condition known as pseudomembranous colitis, which is caused by the antibiotic clindamycin. This is a potential side effect of clindamycin and can lead to severe complications if left untreated. It is important for DS to seek immediate medical attention to properly diagnose and treat this condition. Option A is incorrect because these symptoms are not expected or transient. Option B is incorrect because there is no known interaction between clindamycin and losartan. Option D is incorrect because these symptoms are not flu-related and may be a serious side effect of clindamycin. It is important for DS to seek medical attention and discontinue the use of clindamycin.