Pharmacy PEBC Practice Exam

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Get ready to ace your Pharmacy PEBC Exam with our Practice Exam. Prepare with confidence and assess your readiness with realistic exam simulations.

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RF is an 80 year old female who developed CDAD (Clostridium difficile-associated diarrhea) after recent treatment of a urinary tract infection with ciprofloxacin. She is admitted to hospital with severe symptoms including profound diarrhea (8 watery bowel movements per day), severe abdominal pain, fever (39°C) and confusion. Based on her symptoms, which of the following is the most appropriate therapy choice for her?

Oral fidaxomicin
Oral metronidazole plus intravenous vancomycin
Oral cholestyramine
Oral vancomycin plus intravenous metronidazole

The correct answer is: Oral fidaxomicin

Fidaxomicin is the most appropriate therapy choice for RF's CDAD as it is an orally administered antibiotic that specifically targets and kills Clostridium difficile bacteria while causing minimal disruption to the natural bacteria in the digestive tract. Oral metronidazole plus intravenous vancomycin may also be effective, but may cause more disruption to the patient's natural bacteria. Oral cholestyramine is not a treatment for CDAD and would not be effective in treating RF's symptoms. Oral vancomycin plus intravenous metronidazole may also be effective, but would require both oral and intravenous administration, making it a less optimal choice compared to fidaxomicin.