Pharmacy PEBC Practice Exam

TG, a 43 year old male, is admitted to the Emergency Room following a car accident. TG is diagnosed with an open femur fracture. In the trauma treatment area, the extensive leg wound requires thorough cleaning prior to fracture reduction. TG did not take any medications prior to the accident and is not known to have any medical conditions. Following the fracture reduction surgery, TG is transferred from the emergency department to the orthopedics ward for monitoring before he can be discharged to a rehabilitation center. Which of the following therapies for deep vein thrombosis prophylaxis is the most appropriate while TG remains bedridden?

1. Clopidogrel

2. Enoxaparin

3. Warfarin

4. Rivaroxaban

The correct answer is: Enoxaparin

Enoxaparin is the most appropriate therapy for deep vein thrombosis prophylaxis in this scenario. This is because enoxaparin is a low molecular weight heparin, typically given as a subcutaneous injection, which helps prevent blood clots from forming. While clopidogrel, warfarin, and rivaroxaban are also used for blood clot prevention, they are not as effective for a person who is bedridden. Additionally, clopidogrel and warfarin have specific contraindications and monitoring requirements that may not be suitable for TG in this situation. Rivaroxaban, while effective, is an oral medication and may not be feasible for TG who is not able to move around. Therefore, enoxaparin is the most appropriate and safe option for deep vein thrombosis prophylaxis for TG in this case.